| dc.creator |
Hitchcock, Caitlin |
|
| dc.creator |
Gormley, Siobhan |
|
| dc.creator |
O'Leary, Cliodhna |
|
| dc.creator |
Rodrigues, Evangeline |
|
| dc.creator |
Wright, Isobel |
|
| dc.creator |
Griffiths, Kirsty |
|
| dc.creator |
Gillard, Julia |
|
| dc.creator |
Watson, Peter |
|
| dc.creator |
Hammond, Emily |
|
| dc.creator |
Werner-Seidler, Aliza |
|
| dc.creator |
Dalgleish, Timothy |
|
| dc.date |
2018-02-16T13:11:19Z |
|
| dc.date |
2018-02-16T13:11:19Z |
|
| dc.date |
2018-01-29 |
|
| dc.date.accessioned |
2019-03-20T08:23:08Z |
|
| dc.date.available |
2019-03-20T08:23:08Z |
|
| dc.identifier |
https://www.repository.cam.ac.uk/handle/1810/273286 |
|
| dc.identifier |
10.17863/CAM.20309 |
|
| dc.identifier.uri |
https://evidence.thinkportal.org/handle/123456789/32237 |
|
| dc.description |
INTRODUCTION: Major depressive disorder (MDD) is a chronic condition. Although current treatment approaches are effective in reducing acute depressive symptoms, rates of relapse are high. Chronic and inflexible retrieval of autobiographical memories, and in particular a bias towards negative and overgeneral memories, is a reliable predictor of relapse. This randomised controlled single-blind trial will determine whether a therapist-guided self-help intervention to ameliorate autobiographical memory biases using Memory Flexibility training (MemFlex) will increase the experience of depression-free days, relative to a psychoeducation control condition, in the 12 months following intervention. METHODS AND ANALYSIS: Individuals (aged 18 and above) with a diagnosis of recurrent MDD will be recruited when remitted from a major depressive episode. Participants will be randomly allocated to complete 4 weeks of a workbook providing either MemFlex training, or psychoeducation on factors that increase risk of relapse. Assessment of diagnostic status, self-report depressive symptoms, depression-free days and cognitive risk factors for depression will be completed post-intervention, and at 6 and 12 months follow-up. The cognitive target of MemFlex will be change in memory flexibility on the Autobiographical Memory Test- Alternating Instructions. The primary clinical endpoints will be the number of depression-free days in the 12 months following workbook completion, and time to depressive relapse. ETHICS AND DISSEMINATION: Ethics approval has been granted by the NHS National Research Ethics Committee (East of England, 11/H0305/1). Results from this study will provide a point-estimate of the effect of MemFlex on depressive relapse, which will be used to inform a fully powered trial evaluating the potential of MemFlex as an effective, low-cost and low-intensity option for reducing relapse of MDD. TRIAL REGISTRATION NUMBER: NCT02614326. |
|
| dc.description |
This work is supported by a grant to TD from the UK Medical Research Council, grant number MC_US_A060_0019. |
|
| dc.language |
eng |
|
| dc.language |
en |
|
| dc.publisher |
BMJ |
|
| dc.publisher |
BMJ Open |
|
| dc.rights |
Attribution 4.0 International |
|
| dc.rights |
http://creativecommons.org/licenses/by/4.0/ |
|
| dc.subject |
adult psychiatry |
|
| dc.subject |
clinical trials |
|
| dc.title |
Study protocol for a randomised, controlled platform trial estimating the effect of autobiographical Memory Flexibility training (MemFlex) on relapse of recurrent major depressive disorder. |
|
| dc.type |
Article |
|