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A cluster randomized controlled platform trial comparing group MEmory specificity training (MEST) to group psychoeducation and supportive counselling (PSC) in the treatment of recurrent depression.

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dc.creator Werner-Seidler, Aliza
dc.creator Hitchcock, Caitlin
dc.creator Bevan, Anna
dc.creator McKinnon, Anna
dc.creator Gillard, Julia
dc.creator Dahm, Theresa
dc.creator Chadwick, Isobel
dc.creator Panesar, Inderpal
dc.creator Breakwell, Lauren
dc.creator Mueller, Viola
dc.creator Rodrigues, Evangeline
dc.creator Rees, Catrin
dc.creator Gormley, Siobhan
dc.creator Schweizer, Susanne
dc.creator Watson, Peter
dc.creator Raes, Filip
dc.creator Jobson, Laura
dc.creator Dalgleish, Timothy
dc.date 2018-07-13T12:05:26Z
dc.date 2018-07-13T12:05:26Z
dc.date 2018-06
dc.date.accessioned 2019-03-20T08:23:14Z
dc.date.available 2019-03-20T08:23:14Z
dc.identifier https://www.repository.cam.ac.uk/handle/1810/278089
dc.identifier 10.17863/CAM.25426
dc.identifier.uri https://evidence.thinkportal.org/handle/123456789/32271
dc.description Impaired ability to recall specific autobiographical memories is characteristic of depression, which when reversed, may have therapeutic benefits. This cluster-randomized controlled pilot trial investigated efficacy and aspects of acceptability, and feasibility of MEmory Specificity Training (MEST) relative to Psychoeducation and Supportive Counselling (PSC) for Major Depressive Disorder (N = 62). A key aim of this study was to determine a range of effect size estimates to inform a later phase trial. Assessments were completed at baseline, post-treatment and 3-month follow-up. The cognitive process outcome was memory specificity. The primary clinical outcome was symptoms on the Beck Depression Inventory-II at 3-month follow-up. The MEST group demonstrated greater improvement in memory specificity relative to PSC at post-intervention (d = 0.88) and follow-up (d = 0.74), relative to PSC. Both groups experienced a reduction in depressive symptoms at 3-month follow-up (d = 0.67). However, there was no support for a greater improvement in depressive symptoms at 3 months following MEST relative to PSC (d = -0.04). Although MEST generated changes on memory specificity and improved depressive symptoms, results provide no indication that MEST is superior to PSC in the resolution of self-reported depressive symptoms. Implications for later-phase definitive trials of MEST are discussed.
dc.format Print-Electronic
dc.language eng
dc.publisher Behaviour research and therapy
dc.rights Attribution 4.0 International
dc.rights http://creativecommons.org/licenses/by/4.0/
dc.title A cluster randomized controlled platform trial comparing group MEmory specificity training (MEST) to group psychoeducation and supportive counselling (PSC) in the treatment of recurrent depression.
dc.type Article


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