| dc.contributor |
Susumu Tonegawa. |
|
| dc.contributor |
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. |
|
| dc.contributor |
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. |
|
| dc.creator |
Jaime-Bustamante, Kean (Kean Willyams) |
|
| dc.date |
2018-03-12T19:28:52Z |
|
| dc.date |
2018-03-12T19:28:52Z |
|
| dc.date |
2017 |
|
| dc.date |
2017 |
|
| dc.date.accessioned |
2019-05-10T17:26:21Z |
|
| dc.date.available |
2019-05-10T17:26:21Z |
|
| dc.identifier |
http://hdl.handle.net/1721.1/114076 |
|
| dc.identifier |
1027213794 |
|
| dc.identifier.uri |
https://evidence.thinkportal.org/handle/1721.1/114076 |
|
| dc.description |
Thesis: Ph. D. in Neuroscience, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2017. |
|
| dc.description |
Cataloged from PDF version of thesis. |
|
| dc.description |
Includes bibliographical references. |
|
| dc.description |
The amygdala is a structure well known for its role in fear and reward learning, but how these mechanisms are used for decision-making is not well understood. Decision-making involves the rapid updating of cue associations as well as the encoding of a value currency, both processes in which the amygdala has been implicated. In this thesis I develop a strategy to study value-guided decision making in rodents using an olfactory binary choice task. Using a logistic regression model, I show that the value of expected rewards is a strong influence on choice, and can bias perceptual decisions. In addition, I show that decisions are influenced by events in the near past, and a specific bias towards correct choices in the near past can be detected using this analysis. Using genetic targeting of a sub-population of amygdala neurons, I show that this population is required for the rapid learning of an olfactory decision making task. Using in-vivo calcium imaging of this population I show that these neurons are active during the inter-trial interval and modulated by choice history, suggesting a mechanism by which choice history can influence current decisions. |
|
| dc.description |
by Kean Jaime-Bustamante. |
|
| dc.description |
Ph. D. in Neuroscience |
|
| dc.format |
122 pages |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Massachusetts Institute of Technology |
|
| dc.rights |
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. |
|
| dc.rights |
http://dspace.mit.edu/handle/1721.1/7582 |
|
| dc.subject |
Brain and Cognitive Sciences. |
|
| dc.title |
The amygdala in value-guided decision making |
|
| dc.type |
Thesis |
|