Perinatal asphyxia as the leading cause of death and brain injury of newborns: prognosis and neuroprotection of long-term outcomes []

dc.creator	Herrera-Marschitz, Mario
dc.creator	Golubnitchaja, Olga
dc.creator	Bustamante, Diego
dc.creator	Morales, Paola
dc.creator	Klawitter, Verena
dc.creator	Fiedler, Jenny L.
dc.creator	Morelli, Micaela
dc.creator	Tasker, Andrew
dc.creator	Gomez-Urquijo, Sonia
dc.creator	Hökfelt, Tomas
dc.creator	Goiny, Michel
dc.date	2007-11-01T00:00:00Z
dc.date.accessioned	2015-07-20T22:47:18Z
dc.date.available	2015-07-20T22:47:18Z
dc.identifier	1860-7446
dc.identifier	1860-3572
dc.identifier	https://doaj.org/article/a58539730aa24fa8a23ee2522e712a18
dc.identifier.uri	http://evidence.thinkportal.org/handle/123456789/23640
dc.description	[english] Interruption of oxygen availability and re-oxygenation at birth implies a severe metabolic insult, affecting the development of the central nervous system (CNS), increasing its vulnerability to challenges occurring at adult stages. It has been reported that perinatal asphyxia produces regionally specific neuronal decrease and neurite atrophy in basal ganglia, and hippocampus. In hippocampus, a concomitant increase of neurogenesis and neurite hypertrophy has also been observed. The potential neuroprotection of nicotinamide, a non-selective inhibitor of poly (ADP-ribose) polymerase (PARP-1), has been investigated, finding functional and morphological improvements when administered 24h after the insult (0.8 mmol/kg, i.p., 24, 48 and 72 h after birth.). The main effect of nicotinamide has been seen in neostriatum, preventing an asphyxia-induced decrease of the number of nNOS cells, and nNOS- and dopamine-like neurite atrophy. The present results support the idea that nicotinamide can prevent the effects elicited by a sustained energy-failure condition, as occurring during perinatal asphyxia, enlightening the enzyme PARP-1 as a novel target for neuronal protection. The support by FONDECYT, ICBM-Enlace, DAAD-CONICYT Programme-2007 grants is acknowledged.
dc.publisher	German Medical Science GMS Publishing House
dc.relation	http://www.egms.de/static/en/journals/zma/2007-24/zma000467.shtml
dc.relation	https://doaj.org/toc/1860-7446
dc.relation	https://doaj.org/toc/1860-3572
dc.rights	CC BY-NC-ND
dc.source	GMS Zeitschrift für Medizinische Ausbildung, Vol 24, Iss 4, p Doc173 (2007)
dc.subject	Special aspects of education
dc.subject	LC8-6691
dc.subject	Education
dc.subject	L
dc.subject	DOAJ:Education
dc.subject	DOAJ:Social Sciences
dc.subject	Special aspects of education
dc.subject	LC8-6691
dc.subject	Education
dc.subject	L
dc.subject	DOAJ:Education
dc.subject	DOAJ:Social Sciences
dc.subject	Special aspects of education
dc.subject	LC8-6691
dc.subject	Education
dc.subject	L
dc.subject	Special aspects of education
dc.subject	LC8-6691
dc.subject	Education
dc.subject	L
dc.subject	Education
dc.subject	L
dc.subject	Special aspects of education
dc.subject	LC8-6691
dc.title	Perinatal asphyxia as the leading cause of death and brain injury of newborns: prognosis and neuroprotection of long-term outcomes []
dc.type	article