Based on the need to develop the nation’s science and technological advancement through science education, science educationists are searching for a suitable learning model that integrates innovative technological thinking. One way in conceptualizing this learning model, this study seeks to understand the thinking of scientist entrepreneurs who had produced innovative products for their business ventures. A case study approach was employed. The qualitative findings showed that the respondents integrated entrepreneurial thinking and science process skills in producing their innovative science based products. As a result, we proposed five entrepreneurial science thinking steps which can be used as a learning model in the science curriculum at both primary and secondary school levels.