The purpose of this study was to investigate the effects of integrated information literacy in first-grade science curriculum on students’ science learning. In this quasi-experimental study, two first-grade classrooms from a public elementary school were randomly assigned into the experimental group and control group. The former accepted an inquiry-based science curriculum infused information literacy using the Super3 model, while the latter accepted the traditional lecture-oriented instruction. The instructional unit in both experimental and control groups was taught by the same science teacher and lasted around three weeks, seven periods of time per week. Two tests were designed to test student’s memory of factual information and comprehension of scientific concepts. Results from the analyses of covariance showed that the experimental group significantly outperformed their counterparts on two measures of science learning. It is suggested that integrated information literacy instruction could have a positive impact on first-graders’ subject content learning and lay a foundation for young children to be lifelong learners.