The process of teaching students is of the greatest importance. It is important to study how to manage it to achieve the best advantages to the students and the university. The authors propose to apply the methods and tools of knowledge management and e-learning. The potential of knowledge management lies in the optimization of university processes, in introducing organizational learning and in helping to take well grounded decisions. The potential of e-learning lies in the improvement of the quality of education, in higher flexibility and adaptability of teaching process to the needs of individual students and in lowering the cost of education. The article shows how to apply e-portfolios and information systems to support the teaching process and knowledge management at academic institutions.