Introduction: Social intelligence and entrepreneurship are among features leading to the academic and career achievements. Due to the importance of this issue, the present study was performed to determine the level of entrepreneurial skills in students of Kermanshah University of Medical Sciences and its association with social intelligence. Methods: In this descriptive cross-sectional study by using systematic random sampling method, we selected 350 students at Kermanshah University of Medical Sciences. Data were collected using entrepreneurial skills standard and social intelligence questionnaires. Reliability and validity of two questionnaires have been already assessed in previous studies. Results analyzed by descriptive statistics and Pearson correlation coefficient test. Results: Students’ entrepreneurial skill was totally 255.69 which is assessed at poor scores range. Research findings also indicated the presence of a statistically significantly positive association between social intelligence and risk-taking (r=0.14 P=0.035), locus of control (r=0.72, P=0.019), need to achievement (r=0.54, P=0.012), mental health (r=0.53, P=0.033), pragmatism (r=0.45, P=0.04), ambiguity toleration (r=0.58, P=0.029), positive thinking (r=0.72, P=0.019), and challenging (r=0.29, P=0.016). Conclusion: Given the students’ poor entrepreneurial skills and the correlation between social intelligence and entrepreneurial components, it is recommended to strengthen social intelligence and consequently promote entrepreneurial skills.