This paper reports presents the results of a research developed with students of the high school in the Dourados, Mato Grosso do Sul, with the objective of proposing a theoretical-experimental teaching sequences, potentially significant, approaching the theme Intermolecular Interactions. The teaching sequence was developed with 44 students of the last year of the high school, with the duration of 9 classes of 50 minutes. The methodology presents the characteristics of the qualitative research, being based on David Ausubel's theoretical. We used, as advance organizer, the test determination of the ethanol content in gasoline, adapting, along the experiments, to the use of the natural dyes of the urucum seeds communly used through the region the research was done. The instruments used to collect the information was through the use of questionnaires and observations of the classes. At the end 32 students presented arguments, developing in each stage, as well as in participation, as in classroom discussion, evidencing the evolution conceptual on the process of significant learning.