The author presents the results of the research of the theoretical and organizational approaches to the creation of services of complex support of professional education of persons with disabilities in institutions of primary and secondary professional education. This service provides creation of necessary conditions for high-quality professional education and prevention of social and personal debts of students with physical and sensory impairments, persistent educational difficulties due to social or organic causes. The article considers the main features and options for the institutionalization of services of complex support, identifies the conditions of its successful work.