This paper considers some of the major challenges facing key stakeholders, including teachers, professionals working in support services, parents and pupils, as they strive to improve services for children with social, emotional and behavioural difficulties (SEBD). For each of these challenges (working with families, low educational attainments, including pupils with SEBD in mainstream schools, transition from school to college or employment, early intervention and prevention) we review research evidence, mainly from the UK and USA, and discuss possible solutions. A key theme in the paper, discussed in the concluding section, is that governments, local authorities and schools, should use the research evidence to develop carefully planned and evidence based interventions that will lead to sustained improvements being made in the education of these vulnerable young people.