It is exposed the specific character of the notion of interaction as one of the leading categories in pedagogy. Here it is substantiated that investigation of such a versatile phenomenon as pedagogical interaction can be perfect only on condition of strictly denoted frame of its functioning. Appealing to the history of development of pedagogical interaction of students and teachers promotes a process of renovation of the content of the high education and forms of its organization with the regard to the home specificity of genesis of the pedagogical knowledge.