In this research, our aim was to determine students’ perception level of attitude and self efficacy towards chemistry and to put forth effects of these variables on chemistry achievement for consideration (in other words, to determine how the chemistry achievement were predicted by these variables). In this point of view the research was conducted with 819 students studying at the 1st, 2nd and the 3rd grade of 10 high schools which are located in the city center of Mersin. Addressed to research problems, data was analyzed via descriptive, correlation, linear and multiple regression statistical analyses. As a result it is determined that 2nd graders group of high schools has maximum attitude scores and the attitude towards chemistry lesson, on its own, is a significant predictor of chemistry achievement. it is also determined that 2nd graders group of high schools has maximum self efficacy scores and the self efficacy towards chemistry lesson, on its own, is a significant predictor of chemistry achievement.